教授 博士生导师
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新型基因组编辑技术研发及植物基因组编辑技术开发与育种应用
教授,博士生导师;入选国家级青年人才、江苏省杰青、中国科协“青年人才托举工程”和江苏省“双创博士”等计划。2020年获中国科学院遗传与发育生物学研究所博士学位;同年,作为高层次引进人才加入作物遗传与种质创新利用全国重点实验室水稻遗传与种质创新团队。先后荣获新疆维吾尔自治区优秀硕士学位论文、中国科学院院长优秀奖、中国科学院百篇优秀博士论文等奖项。研究方向为新型基因组编辑技术研发及植物基因组编辑技术开发与育种应用。主持国家级青年人才项目、国家重点研发计划课题、国家自然科学基金青年基金、江苏省杰出青年基金等项目5项。在Cell, Nature Reviews Molecular Cell Biology, Nature Biotechnology, Genome Biology, Plant Cell, Plant Biotechnology Journal, Journal of Integrative Plant Biology等国际期刊发表SCI论文15篇,累积引用3200余次(Google Scholar)。授权美国专利1项,申请国内专利6项,国际专利4项。
谷歌学术主页
https://scholar.google.com.hk/citations?user=MmfT5CkAAAAJ&hl=zh-CN
论文发表情况(*通讯作者;1共同第一作者)
1. Ge Y1, Chen G1, Cheng, X1, Li C, Tian Y, Chi W, Li J, Dai Z, Wang C, Duan E, Liu Y, Sun Z, Li J, Wang B, Xu D, Sun X, Zhang H, Zhang W, Wang C*, Wan J*. (2024) The superior allele LEA12OR in wild rice enhances salt tolerance and yield. Plant Biotechnology Journal, 22, 2971–2984.
2. Xu G1, Liu Y1, Yu S1, Kong D1, Tang K, Dai Z, Sun J, Cheng C, Deng C, Yang Z, Tang Q, Li C*, Su J*, Zhang X*. (2024) CsMIKC1 regulates inflorescence development and grain production in Cannabis sativa plants. Horticulture Research, uhae161, https://doi.org/10.1093/hr/uhae161
3. Sun Y1, Hu J1, Hu Z1, Zhou H, Gao Y, Liu Y, Ji Y, Xu G, Guo Y, Zhang Y, Tian Y, Liu X, Zhou S, Liu Y, Li T, Li C*, Wan J*. (2024) Engineer and split an efficient hypercompact CRISPR–CasΦ genome editor in plants. Plant Communications, 5, 100881.
4. Zhou S1, Cai L1, Wu H1, Wang B, Gu B, Cui S, Huang X, Xu Z, Hao B, Hou H, Hu Y, Li C, Tian Y, Liu X, Chen L, Liu S, Jiang L, Wan J*. (2024) Fine tuning rice heading date through multiplex editing of the regulatory regions of key genes by CRISPR-Cas9. Plant Biotechnology Journal, 22, 751-758.
5. Zhang A1, Shan T1, Sun Y1, Chen Z, Hu J, Hu Z, Ming Z, Zhu Z, Li X, He J, Liu S, Jiang L, Dong X, Wu Y, Wang Y, Liu Y, Li C*, Wan J*. (2023) Directed evolution rice genes with randomly multiplexed sgRNAs assembly of base editors. Plant Biotechnology Journal, 21, 2597-2610.
6. Wang C1, Wang J1, Lu J1, Xiong Y1, Zhao Z, Yu X, Zheng X, Li J, Lin Q, Ren Y, Hu Y, He X, Li C, Zeng Y, Miao R, Guo M, Zhang B, Zhu Y, Zhang Y, Tang W, Wang Y, Hao B, Wang Q, Cheng S, He X, Yao B, Gao J, Zhu X, Yu H, Wang Y, Sun Y, Zhou C, Dong H, Ma X, Guo X, Liu X, Tian Y, Liu S, Wang C, Cheng Z, Jiang L, Zhou J, Guo H, Jiang L, Tao D, Chai J, Zhang W, Wang H*, Wu C*, Wan J*. (2023) A natural gene drive system confers reproductive isolation in rice. Cell, 186, 3577-3592.
7. Wang P1, Li Y1, Liu Z1, Li X1, Wang Y, Liu W, Li X, Hu J, Zhu W, Wang C, Li S, Gu T, Xu D, Tang C, Wang Y, Li C, Zhang S, Wu J*. (2023) Reciprocal regulation of flower induction by ELF3α and ELF3β generated via alternative promoter usage. The Plant Cell, 35, 2095-2113.
8. Zhu H1, Li C1, and Gao C*. (2020) Applications of CRISPR–Cas in agriculture and plant biotechnology. Nature Reviews Molecular Cell Biology, 21: 661-677. (ESI Highly Cited Papers)
9. Li C, Zong Y, Jin S, Zhu H, Lin D, Li S, Qiu JL, Wang Y*, Gao C*. (2020) SWISS: multiplexed orthogonal genome editing in plants with a Cas9 nickase and engineered CRISPR RNA scaffolds. Genome Biology, 21, 141.
10. Li C1, Zhang R1, Meng X1, Chen S, Zong Y, Lu C, Qiu JL, Chen YH, Li J*, Gao C*. (2020) Targeted, random mutagenesis of plant genes with dual cytosine and adenine base editors. Nature Biotechnology, 38, 875-882. (Recommended in F1000Prime, ESI Highly Cited Papers)
11. Li C1, Zong Y1, Wang Y1, Jin S, Zhang D, Song Q, Zhang R, Gao C*. (2018) Expanded base editing in crop plants using a Cas9-adenosine deaminase fusion. Genome Biology, 19, 59.
12. Zong Y1, Song Q1, Li C, Jin S, Zhang D, Wang Y, Qiu JL, Gao C*. (2018) Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A. Nature Biotechnology, 36, 950-953.
13. Zong Y1, Wang Y1, Li C, Zhang R, Chen K, Ran Y, Qiu JL, Wang D, Gao C*. (2017) Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion. Nature Biotechnology, 35, 438-440.
14. Li C, Zhang Y, Zhang K, Guo D, Cui B, Wang X, Huang X*. (2015) Promoting flowering, lateral shoot outgrowth, leaf development, and flower abscission in tobacco plants overexpressing cotton FLOWERING LOCUS T (FT)-Like gene GhFT1. Frontiers in Plant Science, 6, 454.
15. Guo D1, Li C1, Dong R, Li X, Xiao X, Huang X*. (2015) Molecular cloning and functional analysis of the FLOWERING LOCUS T (FT) homolog GhFT1 from Gossypium hirsutum L. Journal of Integrative Plant Biology, 57, 522-533.
科研项目
1. 国家重点研发计划,2023YFD1202900,主要农作物基因编辑种质精准创制技术,2023.12 – 2028.11,在研,课题主持
2. 江苏省杰出青年基金项目,SBK2023010234,植物基因组编辑技术开发与应用,2023.09 – 2026.08,在研,主持
3. 国家自然科学基金青年科学基金项目,32201227,植物高效小型化CRISPR/Cas基因组编辑系统的开发研究,2023.01 – 2025.12,在研,主持
4. 海南省崖州湾种子实验室揭榜挂帅项目,B21HJ1004,作物精准编辑技术研发与种质优化,2021.12 – 2024.12,在研,联合主持
5. 中国科协第六届青年人才托举工程,2020QNRC001,植物内源基因定向进化技术和策略的开发及应用,2020.09 – 2023.09,已结题,主持
6. 南京农业大学高层次引进人才启动资金,2020-2025,主持
所获荣誉
2021.08,中国科学院优秀博士学位论文
2019.12,中国科学院大学朱李月华优秀博士生奖
2018.11,博士研究生国家奖学金
2018.07,中国科学院院长优秀奖
2018.06,中国科学院大学三好学生
2016.03,新疆维吾尔自治区优秀硕士学位论文
2015.06,石河子大学优秀毕业研究生
2012.06,石河子大学优秀本科毕业论文
中国科学院大学/中国科学院遗传与发育生物学研究所 遗传学 博士研究生毕业 理学博士学位
石河子大学 遗传学 硕士研究生毕业 理学硕士学位
石河子大学 生物技术 大学本科毕业 理学学士学位
南京农业大学农学院 教学科研