何亚洲博士，现任南京农业大学植物保护学院教授，博士生导师。2019年获浙江大学农学博士学位，2021年10月入职南京农业大学植物保护学院。研究成果发表于PNAS，mSystems，Insect Biochemistry and Molecular Biology, Journal of Pest Science, Pesticide Biochemistry and Physiology, Insect Science等国内外期刊。

农业害虫严重危害作物生产安全，常造成巨大经济损失，并威胁粮食安全。苏云金芽孢杆菌（简称Bt）及其表达的杀虫蛋白（Bt毒素）在农业害虫防治中具有重大应用价值。基于Bt的害虫防治技术具有特异性强、绿色无污染的优点。课题组围绕害虫—Bt互作机理开展研究，致力于解析Bt杀虫机理、害虫防御机制、以及害虫抗性演化机制，为增强Bt杀虫活性、扩大杀虫谱，开发新型高效害虫防治技术及害虫抗性治理提供理论和技术支撑。

代表性论文:

1.      Yonghui Song, Jie Wang, Xiaohan Yao, Chang Liu, Lu Gao, Lisi Wang, Yihua Yang, Yidong Wu, Ya-Zhou He* (2025). Redundant targeting with multiple sgRNAs enables rapid genetic screening in the lepidopteran pest Helicoverpa armigera. Journal of Pest Science. 99.

2.      Chenyang Wang, Yinuo Zhang, Qiming Sun, Lin Li, Fang Guan, Ya-Zhou He, Yidong Wu* (2025). Species-specific evolution of lepidopteran TspC5 tetraspanins associated with dominant resistance to Bacillus thuringiensis toxin Cry1Ac. Journal of Integrative Agriculture. 24: 3127-3140.

3.      Jia-Lin Wang, Zi-Qian Zhong, Ya-Zhou He, Jun-Hua Tian, Yu-Feng Wang, Alexander S Raikhel (2025). The ecdysone-induced bZIP transcription factor MafB establishes a positive feedback loop to enhance vitellogenesis and reproduction in the Aedes aegypti mosquito. PNAS, 122: e2411688122.

4.      Chenyang Wang, Yinuo Zhang, Fang Guan, Ya-Zhou He*, Yidong Wu* (2024). Genome-wide identification and phylogenetic analysis of the tetraspanin gene family in lepidopteran insects and expression profiling analysis in Helicoverpa armigera. Insect science. 32:471-486.

5.      Kaixia Li, Shan Yu, Yihua Yang, Ya-Zhou He*, Yidong Wu* (2023). Mechanisms of feeding cessation in Helicoverpa armigera larvae exposed to Bacillus thuringiensis Cry1Ac toxin, Pesticide Biochemistry and Physiology 195: 105565.

6.      Shan Yu, Chenyang Wang, Kaixia Li, Yihua Yang, Ya-Zhou He*, Yidong Wu* (2022). Transcriptional analysis of cotton bollworm strains with different genetic mechanisms of resistance and their response to Bacillus thuringiensis Cry1Ac toxin. Toxins (Basel) 14: 366.

7.      Ya-Zhou He, Emre Aksoy, Yike Ding, Alexander S. Raikhel* (2021). Hormone-dependent activation and repression of microRNAs by the ecdysone receptor in the Dengue vector mosquito Aedes aegypti. PNAS 118: e2102417118.

8.      Ya-Zhou He, Yu-Meng Wang, Tian-Yan Yin, Wilmer Cuellar, Shu-Sheng Liu, Xiao-Wei Wang* (2021). Gut-expressed vitellogenin facilitates the movement of a plant virus across the midgut wall in its insect vector. mSystems 6: e00581-21.

9.      Ya-Zhou He, Yike Ding, Xueli Wang, Zhen Zou, Alexander S. Raikhel* (2021). E93 confers steroid hormone responsiveness of digestive enzymes to promote blood meal digestion in the midgut of the mosquito Aedes aegypti. Insect Biochemistry and Molecular Biology 134: 103580.

10.  Ya-Zhou He, Yu-Meng Wang, Tian-Yan Yin, Elvira Fiallo-Olivé, Yin-Quan Liu, Linda Hanley-Bowdoin, Xiao-Wei Wang* (2020). A plant DNA virus replicates in the salivary glands of its insect vector via recruitment of host DNA synthesis machinery. PNAS 117: 16928-16937.