以进化基因组学、多组学生物信息学为核心技术手段，将药用植物作为核心研究对象，主攻药用植物特征活性次生代谢物的合成通路解析与演化机制研究，同步结合系统发育基因组学解析药用植物物种分化、基因组演化规律。

课题组聚焦药用植物基因组的组装和解析，关注端粒到端粒（T2T）、多倍体、超大型的复杂药用植物基因组，利用精准的组装、注释来分析药用植物基因组的形成和演化规律；结合系统发育和比较基因组学手段，追溯药用植物起源分化历程，探索药效代谢通路的形成与多样化机制。具体方向包括1）聚焦伞形科、桑科、芸香科  等类群中的复杂香豆素，解析呋喃/吡喃型香豆素完整生物合成通路，揭示该类药效成分在被子植物中“镶嵌式”不均衡分布的分子演化机制；2）以唇形科夏枯草、薄荷等药用植物为材料，搭建多组学联合筛选功能酶的高效分析流程，挖掘萜类合成关键酶基因和代谢调控网络，揭示唇形科物种萜类产物多样性和差异性机制。3）以百合、贝母等超大型基因组为对象，解析超大型基因组的形成和特征性代谢产物。

以第一作者或通讯作者（含共同）在Cell Genomics、Nature Communications、Nature Plants、Nature Genetics、The Innovation、Trends in Plant Science、The Plant Journal、Plant Communications、Plant Biotechnology Journal、Plant Physiology、Engineering等期刊发表研究论文40余篇，详细信息请见ORCID: 0000-0002-7128-9935。

团队诚招博士后和硕博研究生，欢迎有意者加入。

招生寄语：

(1) Motivation 对于科研有兴趣，对于自己有要求

(2) Determination 有决心做好一件事

(3) Persistence 科研之路不是坦途，面对挫折失败能坚持 

本人属于理想主义科研工作者，对于科学有一定追求，只想混个文凭者勿扰!

代表性成果

科研论文：（共同第一作者^#，通讯作者*）

1.      Zhang J^#, Liang Y^#, Liu G^#, Bai Y^#, Huang XC^#, Bai Y, Garcia-Caparros P, Zhu T, Fu J, Zhang H, Chen H, Wang W, Zhang L, Jiang Y*, Xue JY*, Chen F*. 2026. Water lily complete genomes illuminate the innovations of water lilies and early angiosperms. Nature Plants. 12(5):937-953.

2.      Zhou P^#, Liu SJ^#, Huang L^#, Wang Y^#, Jiang X, Dong W, Gong J, Wang L, Wang H, P Li*, Xue JY*, Lu X*. 2026. Chromosome-level genome assembly of the allotetraploid Gynostemma pentaphyllum provides novel insights into the biosynthesis of ginsenoside and gypenoside LVI. Plant Biotechnology Journal. 24(6):4204-4220.

3.      Xue JY*^,#, Yang CA^#, Hu S, Fan HY, Zhang YM, Shao ZQ, Li L, Wang S, Wei T, Dong S, Liu Y, Li Z*, Van de Peer Y*. 2025. Evolution of protein domains and protein domain combinations provides insights into the origin and diversification of land plants. Cell Genomics. 6(4):101107.

4.      Xue JY^#, Liu SJ ^#, Wang J^#, Huang XC, Xu Z, Fang X*, Li Z*, Van de Peer Y*. 2025. Multi-Omics Roadmap to Plant-Derived Medicines. Engineering. https://doi.org/10.1016/j.eng.2025.10.019.

5.      Dong S^#, Wang S^#, Li L^#, Yu J^#, Zhang Y^#, Xue JY^#, Chen H, Ma J, Zeng Y, Cai Y, Huang W, Zhou X, Wu J, Li J, Yao Y, Hu R, Zhao T, Villarreal A JC, Dirick L, Liu L, Ignatov M, Jin M, Ruan J, He Y, Wang H, Xu B, Rozzi R, Wegrzyn J, Stevenson DW, Renzaglia KS, Chen H, Zhang L, Zhang S, Mackenzie R, Moreno JE, Melkonian M, Wei T, Gu Y, Xu X, Rensing SA, Huang J, Long M, Goffinet B, Bowman JL*, Van de Peer Y*, Liu H*, Liu Y*. 2025. Bryophytes hold a larger gene family space than vascular plants. Nature Genetics 57(10):2562–2569.

6.      Hu SY, Shi G, Yang CA, Van de Peer Y*, Li Z*, Xue JY*. 2025. Comprehensive sampling from mitochondrial genomes substantiates the Neoproterozoic origin of land plants. Plant Communications 6(11), 101497.

7.      Wu JY, Zhou GC, Li Z*, Xue JY*. 2025. Tuning Plant Defenses in a Changing World. Trends in Plant Science. 30(10):1069-1071.

8.      Zhou X^#, Fan HY^#, Feng XY^#, Ruan Z^#, Yuan J, Han Q, He Z, You Y, Chao H; Chen M, Shao ZQ*, Xue JY*, Chen D*. 2025. PGCP: A Comprehensive Database of Plant Genomes for Comparative Phylogenomics. Plant Biotechnology Journal. 23(7):2928-2930.

9.      Zhang YM^#, Wei ZY^#, Yang CA, Feng XY, Wang Y, Li SX, Sun XQ*, Shao ZQ*, Xue JY*. 2025. A telomere-to-telomere genome assembly for greater yam (Dioscorea alata). Plant Communications. 6, 101326.

10.  Liu SJ^#, Liu Z^#, Shao BY, Li T, Zhu X, Wang R, Shi L*, Xu S*, Van de Peer Y*, Xue JY*. 2025. Deciphering the biosynthetic pathway of triterpene saponins in Prunella vulgaris. The Plant Journal. 121(2): e17220.

11.  Xu S^#, Chen R^#, Zhang X^#, Wu Y^#, Yang L^#, Sun Z, Zhu Z, Song A, Wu Z, Li T, Jin B, Niu S, Huang XC, Liu SJ, Yang CA, Jia G, He Y, Du F, Chen M, Chen F, Wang W, Sun H, Fu Y, Liao W, Pei H, Wu X, Zheng S, Xue JY*, Ning G*, Ming R*, Teng N*. 2024. The evolutionary tale of lilies: Giant genomes derived from transposon insertions and polyploidization. The Innovation. 5(6): 100726.

12.  Huang XC^#, Tang H^#, Wei X^#, He Y, Hu S, Wu JY, Xu D, Qiao F*, Xue JY*, Zhao Y*. 2024. The gradual establishment of complex coumarin biosynthetic pathway in Apiaceae. Nature Communications. 15, 6864.

13.  Li Q^#, Dai Y^#, Huang XC^#, Sun L, Wang K, Guo X, Xu D, Wan D, An L, Wang Z, Tang H, Qi Q, Zeng H, Qin M*, Xue JY*, Zhao Y*. 2024. The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins. Acta Pharmaceutica Sinica B. 14(8), 3760-3773.

14.  Xue JY^#, Fan HY ^#, Zeng Z ^#, Zhou YH, Hu SY, Li SX, Cheng YJ, Meng XR, Chen F*, Shao ZQ*, Van de Peer Y*. 2023. Comprehensive regulatory networks for tomato organ development based on the genome and RNAome of MicroTom tomato. Horticulture Research. 10(9):uhad147.

15.  Xue JY^#, Li Z^#, Hu SY^#, Kao SM^#, Zhao T^#, Wang JY^#, Wang Y, Chen M, Qiu Y, Fan HY, Liu Y*, Shao ZQ*, Van de Peer Y*. 2023. The Saururus chinensis genome provides insights into the evolution of pollination strategies and herbaceousness in magnoliids. The Plant Journal. 113(5):1021-1034.

16.  Shao ZQ^#, Xue JY^#, Wang Q, Wang B, Chen JQ*. 2019. Revisiting the Origin of Plant NBS-LRR Genes. Trends in Plant Science. 24(1):9-12.

17.  Shao ZQ^#, Xue JY^#, Wu P, Zhang YM, Wu Y, Hang YY, Wang B*, Chen JQ*. 2016. Large-Scale Analyses of Angiosperm Nucleotide-Binding Site-Leucine-Rich Repeat Genes Reveal Three Anciently Diverged Classes with Distinct Evolutionary Patterns. Plant Physiology. 170(4): 2095-2109.

18.  Amborella Genome Project. 2013. The Amborella Genome and the Evolution of Flowering Plants. Science 342 (6165): p. 1241089

发明专利： 

      1.  薛佳宇、刘思杰。夏枯草细胞色素氧化酶CYP蛋白及其编码基因与应用。2025-2-14。中国。CN202410470331.5

      2.  薛佳宇、周广灿、王元涛、张艳梅。抗癌、抗炎多肽Lunasin在哺乳动物细胞CHO-S中的表达、纯化方法。2020-3-31。中国。ZL201710417823.8

      3.  周广灿、王宜磊、薛佳宇、李稳、陈晓、吴雨含。一种旱金莲调控芥酸合成基因及其应用。2020-06-30。中国。CN2019112017877

      4.  薛佳宇、张艳梅、周广灿、雷照、石磊、吴婷婷、王智。6,7-二甲氧基-喹唑啉-4-胺衍生物、其制备方法及医药用途。2017-09-15。中国。ZL201510116327.x