简介：

国家级青年人才获得者（优青），主要研究方向为茄科作物高产优质性状遗传解析及全基因组设计育种。将多组学与全基因组选育、人工智能（AI）等技术深度融合，从全基因组层面系统解析番茄、马铃薯等茄科作物产量及品质等育种难题，加速茄科作物产量与品质的遗传解析及全基因组智能设计育种进程。旨在为茄科作物育种提供科学、精准的决策依据，推动育种模式从“经验育种”向“精准智能育种”的范式转变，显著提升茄科作物的育种效率。

研究领域：茄科作物遗传解析与智能设计育种

主要学术成绩：

1) 开发了利用进化全基因组鉴定功能位点的茄科“进化透镜”新技术，克服了非编码区域功能位点难以鉴定、难以定量的难题；开发了多个马铃薯全基因组选育模型，提出了全基因组预测马铃薯自交系选育及品种改良新依据，为自交系选育及改良提供了全基因组选育的研究体系。

2) 对番茄果实品质、马铃薯块茎性状进行了驯化解析，结合GWAS/QTL、基因调控网络等手段挖掘并验证优异等位基因；开发了番茄风味全基因组预测模型，挖掘并利用优异祖先种种质资源，为番茄果实风味改良以及马铃薯薯块改良提供了丰富的种质资源和遗传基础。

目前，申请人以第一或通讯作者先后在Cell 、Molecular Plant 、Plant Physiology 等高水平期刊发表文章；参与Nature、Cell、Nature Plants等高水平期刊文章多篇；相关研究成果被CCTV详细报道，受到Nature等期刊高亮点评。

招聘与招生：

长期招聘生物信息学、遗传育种、分子生物学相关研究方向的工作人员。

本课题组着重培养研究生大数据处理和挖掘、生物统计、分子实验等科研技能、辩证思考以及独立完成课题的能力；鼓励同学自由探索，提倡同学参加学术会议，增加学术知识面；导师容易沟通，尊重同学情绪，尊重同学个人发展，积极推荐同学深造；欢迎对生物信息学、生物统计、分子生物学感兴趣的同学加入。欢迎对本课题组感兴趣的同学来信或当面交流。

科研项目与获奖

 主持国家自然科学基金优秀青年科学基金、南京农业大学高层次人才、江苏省农业科技自主创新等项目。

 获第四届中国植物生理与植物分子生物学会优秀女青年奖、2023年度中国农业重大科学发现。

发表论文：

Yaoyao Wu^#, Dawei Li^#, Yong Hu^#, Hongbo Li, Guillaume P. Ramstein, Shaoqun Zhou, Xinyan Zhang, Zhigui Bao, Yu Zhang, Baoxing Song, Yao Zhou, Yongfeng Zhou, Edeline Gagnon, Tiina Särkinen, Sandra Knapp, Chunzhi Zhang, Thomas Städler, Edward S. Buckler, Sanwen Huang*. (2023) Phylogenomic discovery of deleterious mutations facilitates hybrid potato breeding. Cell. 第一作者.

Yaoyao Wu^#*, Keyi Ye1^#, Jian Yin, Ran Du, Xue Cao, Hongjun Lyu, Yanling Wang, Yaqing Lyu, Yong Hu, Yuxin Jia, Yuanchao Xu, Sanwen Huang, Jinzhe Zhang*.(2025) Multi-omics reveals the genetic regulation and functions of long non-coding RNAs in tomato. Plant Physiology. 第一作者且通讯

Yaoyao Wu^#, Lynn Johnson^#, Baoxing Song, Cinta Romay, Michelle Stitzer, Adam Siepel, Edward Buckler, Armin Scheben*.  (2022) A multiple alignment workflow shows the effect of repeat masking and parameter tuning on alignment in plants. The Plant Genome15, e20204. 第一作者.

Dan Liu^#, Liang Yang^#, Jinzhe Zhang, Guangtao Zhu, Hongjun Lv, Yaqing Lv, Yanling Wang, Xue CAO, Tianshu Sun, Sanwen Huang*, Yaoyao Wu*. (2019) Domestication and breeding changed tomato fruit transcriptome. Journal of Integrative Agriculture, 19 120–132. 通讯作者.

XufengWang^#, QiuyueChen^#, YaoyaoWu^#, Zachary H.Lemmon, GuanghuiXu, ChengHuang, YamengLiang, DingyiXu, DanLi, John F.Doebley, FengTian*. (2018) Genome-wide analysis of transcriptional variability in a large maize-teosinte population. Molecular Plant 11 443-459. 共同第一作者.

Lin Cheng^#, Nan Wang^#, Zhigui Bao^#, Qian Zhou, Andrea Guarracino,Yuting Yang, Pei Wang,  Zhiyang Zhang, Dié Tang, Pingxian Zhang, Yaoyao Wu, Yao Zhou, Yi Zheng, Yong Hu, Qun Lian, Zhaoxu Ma, Ludivine Lassois, Chunzhi Zhang, William J. Lucas, Erik Garrison, Nils Stein, Thomas Städler, Yongfeng Zhou, Sanwen Huang*. (2025) Leveraging a phased pangenome for haplotype design of hybrid potato, Nature.

Zhiyang Zhang^#; Pingxian Zhang^#,Yiyuan Ding^#,Zefu Wang^#, Zhaoxu Ma,Edeline Gagnon, Yuxin Jia,Lin Cheng,Zhigui Bao,Zinan Liu,Yaoyao Wu,Yong Hu, Qun Lian, Weichao Lin,Nan Wang, Keyi Ye, Hongru WangS,Jinzhe Zhang,Yongfeng Zhou, Liang Liu,Suhua Li, William J.Lucas,Tiina Särkinen, Sandra Knapp*,Loren H. Rieseberg*,Jianquan Liu*,Sanwen Huang*.(2025). Ancient hybridization underlies tuberization and radiation of the potato lineage. Cell.

Yao Zhou^#, Zhiyang Zhang^#, Zhigui Bao^#, Hongbo Li, Yaqing Lyu, Yanjun Zan, Yaoyao Wu, Lin Cheng, Yuhan Fang, Kun Wu, Jinzhe Zhang, Hongjun Lyu, Tao Lin, Qiang Gao, Surya Saha, Lukas Mueller, Zhangjun Fei, Thomas Städler, Shizhong Xu, Zhiwu Zhang, Doug Speed, Sanwen Huang*. (2022) Graph pangenome captures missing heritability and empowers tomato breeding. Nature . 606 527–534.

Dawei Li; Zedong Geng; Shixuan Xia; Hui Feng; Xiuhan Jiang; Hui Du; Pei Wang; Qun Lian; Yanhui Zhu; Yuxin Jia; Yao Zhou; Yaoyao Wu; Chenglong Huang; Guangtao Zhu; Yi Shang; Huihui Li; Thomas Städler; Wanneng Yang; Sanwen Huang; Chunzhi Zhang ; Integrative multi-omics analysis reveals genetic and heterotic contributions to male fertility and yield in potato. Nature Communications, 2024, 15(8652) 

Baoxing Song, Edward S. Buckler, Hai Wang, Yaoyao Wu, Evan Rees, Elizabeth A. Kellogg, Daniel J. Gates, Merritt Khaipho-Burch, Peter J. Bradbury, Jeffrey Ross-Ibarra, Matthew B. Hufford, M. Cinta Romay*. (2021) Conserved noncoding sequences provide insights into regulatory sequence and loss of gene expression in maize. Genome Research 31 1245–1257.

Xingyao Xiong^#, Junbo Gou^#, Qinggang Liao^#, Yanlin Li^#, Qian Zhou, Guiqi Bi, Chong Li, Ran Du, Xiaotong Wang, Tianshu Sun, Lvjun Guo, Haifei Liang, Pengjun Lu, Yaoyao Wu, Zhonghua Zhang, Dae-Kyun Ro, Yi Shang, Sanwen Huang, Jianbin Yan. (2021) The Taxus genome provides insights into paclitaxel biosynthesis.  Nature Plants 7 1026–1036.

Junwei Yang, Bin Liang, Yuemei Zhang, Yun Liu, Shengyuan Wang, Qinqin Yang, Xiaolin Geng, Simiao Liu, Yaoyao Wu, Yingfang Zhu & Tao Lin^* (2022). Genome-wide association study of eigenvectors provides genetic insights into selective breeding for tomato metabolites. BMC Biology 20, 120.

Dan Li, Xufeng Wang, Xiangbo Zhang, Qiuyue Chen, Guanghui Xu, Dingyi Xu, Chenglong Wang, Yameng Liang, Lishuan Wu, Cheng Huang, Jinge Tian, Yaoyao Wu, Feng Tian. (2015) The genetic architecture of leaf number and its genetic relationship to flowering time in maize. New Phytologist 210 256–268.