邵文勇  (副教授)

个人简介

研究领域：

植物病原菌抗药性检测、机制与治理，杀菌剂活性评价与毒理学，靶向杀菌剂创制，经济作物病害生物防治。

  发表论文：

25. Zhang Z H, Zheng X M, Li X, Wamg J, Shi D Y, Fang W P, Chen C J*, Shao W Y**. Point mutations in β2-tubulin endow Neopestalotiopsis clavispora with resistance to carbendazim. Advanced Agrochem, 2026, in press.

24. Shao WY, Wang B R, Chen W C, Wei L L, Chen C J*. Molecular and biochemical characterization of field boscalid-resistant isolates of Alternaria alternata from broccoli and peanut. Plant Disease, 2026, First Look,  https://doi.org/10.1094/PDIS-03-26-0439-RE.

23. Yang S, He W, Chen B, Liu R Q, Wu X Q, Zheng X M, Li J W, Li X J, Gu A G, Chen C Y, Song X S, Chen C J*, Shao W Y**. A novel amino acid substitution S376P in FgCYP51B confers prothioconazole resistance via distinct binding mode in Fusarium graminearum. Advanced Agrochem, 2026, in press.

22. Chen B, Li G, Li R Q, He W, Hu Y, Li J W, Gu A G, Yang S, Chen C Y, Song X S, Shao W Y*, Chen C J*. From virtual screening to functional validation: An MM/GBSA and molecular dynamics drivenstrategy for targeting phytopathogenic fungal ferrochelatase. Journal of Integrative Agriculture, 2026, in press.

21. Chen B, Hu Y, He W, Wang M Y, Liu R Q, Li G, Li J W, Li X J, Gu A G, Yang S, Chen C Y, Song X S, Shao W Y*, Chen C J. G550R Mutation of Histidine Kinase LtOs1 Confers High FludioxonilResistance in Lasiodiplodia theobromae from Avocado. Journal of Agricultural and Food Chemistry, 2026, 74: 21913-21924.

20. Chen B, Hu Y, Zheng X M, Gao S Q X, Li J W, Gu A G, Yang S, Chen C Y, Song X S, Shao W Y*, Chen C J*. Novel A576T or M626I substitutions in the HAMP5 domain of histidine kinase FfOs1 alter ligand-binding pocket to mediate ffudioxonil resistance in Fusarium falciforme. Pesticide Biochemistry and Physiology, 2026, 223:107273. 

19. Cao Y Y, Wu C D, Li X, Zhang Z H, Chen B, Song X S, Chen C J, Xing Y J*, Shao W Y*. The Expression of ABC and MFS Transporter Genes, Not Mutationsat ScCyp51, Is Associated with Difenoconazole Resistance in Stagonosporopsis Cucurbitacearum from Melon Fields. Journal of Agricultural and Food Chemistry, 2026, 74: 13448-13459.

18. Chen B, Hu Y, He W, Li G, Liu R Q, Li J W, Li X J, Wei L L, Gu A G, Yang S, Chen C Y, Song X S, Shao W Y*, Chen C J*.  From AI modelling to validation: A 10-day pipeline for potential lead compounds validation. Pesticide Biochemistry and Physiology, 2026, 216: 106761.

17.   Chen B, Liu R Q, He W, Hu Y, Li J W, Li X J, Gu A G, Yang S, Chen C Y, Song X S, Chen C J*, Shao W Y*.  Triple binding pockets of AtSDH: Reduced afffnity underpins SDHI-resistance in Alternaria tenuissima. Pesticide Biochemistry and Physiology, 2025, 213: 106505.

16. Shao W Y, Wang J R, Zhang Y Q, Zhang C F, Chen J, Chen Y, Fei Z J, Ma Z H*, Sun X P*, Jiao C*.  The jet-like chromatin structure defines active secondary metabolism in fungi. Nucleic Acids Research, 2024, 1-16 .

15. Wen Z Y, Zhang Y Q, Chen Y, Zhao Y F, Shao W Y*, Ma Z H.  Characterization of the fludioxonil and phenamacril dual resistant mutantsof Fusarium graminearum. Pesticide Biochemistry and Physiology, 2024, 200: 105815. 

14. Shao W Y, Sun K W, Ma T L, Jiang, H X, Hahn M, Ma Z H*, Jiao C*, Yin Y N*.  SUMOylation regulates low temperature survival and oxidative DNA damage tolerance in Botrytis cinerea. New Phytologist, 2023, 238: 817-834.

13. Shao W Y, Zhang Y, Chen C J*, Xing Y J*.  Function of the mitochondrial transport protein BcMtp1 in regulating vegetative development, asexual reproduction, stress response, fungicide sensitivity, and virulence of Botrytis cinerea. Journal of Fungi, 2023, 9: 25. 

12. Wen Z Y, Wang J R, Jiao C, Shao W Y*, Ma, Z H. Biological and molecular characterizations of field fludioxonil-resistant isolates of Fusarium graminearum. Pesticide Biochemistry and Physiology, 2022, 184: 105101. 

11. Liu K, Wen, Z Y, Ma Z H, Shao W Y*. Biological and molecular characterizations of fluxapyroxad-resistant isolates of Botrytis cinerea. Phytopathology Research, 2022, 4: 2. 

10. Zhang L X, Sun K W, Li Y Q, Ma T L, Zhang Y, Yin Y N, Zhang S*, Shao W Y*. The importin FgPse1 is required for vegetative development, virulence, and deoxynivalenol production by interacting with the nuclear polyadenylated RNA-binding protein FgNab2 in Fusarium graminearum. Phytopathology, 2022, 112: 1072-1080.

9. Shao W Y, Wang J R, Wang H Y, Wen Z Y, Liu C, Zhang Y, Zhao Y F, Ma Z H*. Fusarium graminearum FgSdhC1 point mutation A78V confers resistance to the succinate dehydrogenase inhibitor pydiflumetofen. Pest Management Science,  2022, 78: 1780-1788. 

8. Shao W Y, Zhao Y F, Ma Z H*.  Advances in understanding fungicide resistance in Botrytis cinerea in China. Phytopathology, 2020, 111: 455-463. 

7. Shao W Y, Sun J T, Zhang X K, Chen C J*. Amino acid polymorphism in Succinate dehydrogenase subunit C involved in biological fitness of Botrytis cinerea. Molecular Plant-Microbe Interactions, 2020, 33: 580-589.

6. Xu L, Wang M, Tang G, Ma Z H, Shao W Y*. The endocytic cargo adaptor complex is required for cell-wall integrity via interacting with the sensor FgWsc2B in Fusarium graminearum. Current Genetics,  2019, 65: 1-10. 

5. Shao W Y, Lv C Y, Zhang Y, Wang J and Chen C J*.  Involvement of BcElp4 in vegetative development, various environmental stress response and virulence of Botrytis cinerea. Microbial Biotechnology, 2017, 10: 886-895.

4. Shao W Y, Zhang Y, Wang J, Lv C Y and Chen C J*.  BcMtg2 is required for multiple stress tolerance, vegetative development and virulence in Botrytis cinerea. Scientific Reports, 2016, 6: 28673. 

3. Shao W Y, Yang Y L, Zhang Y, Lv C Y, Ren W C and Chen C J*.  Involvement of BcStr2 in methionine biosynthesis, vegetative differentiation, multiple stress tolerance and virulence in Botrytis cinerea. Molecular Plant Pathology, 2016, 17: 438-447. 

2. Shao W Y, Ren W C, Zhang Y, Hou Y P, Duan Y B, Wang J X, Zhou M G and Chen C J*. Baseline sensitivity of natural populations and characterization of resistant strains of Botrytis cinerea to fluazinam. Australasian Plant Pathology, 2015, 44: 358. 

1. Shao W Y, Zhang Y, Ren W C and Chen C J*.  Physiological and biochemical characteristics of laboratory induced mutants of Botrytis cinerea with resistance to fluazinam. Pesticide Biochemistry and Physiology, 2014, 117: 19-23. 

主持科研项目：

l  靶向赤霉病菌基因组三维构象调控核心蛋白FgSCC1的化合物开发及其抑菌控毒机制研究, 国家自然科学基金委员会, 面上项目（32572877），49万元，2026-01至2029-12，在研，主持。

l  热激蛋白BcHsp70类泛素化调控灰葡萄孢低温适应性的机制研究，国家自然科学基金委员会，青年基金项目（31901828），2020-01至2022-12。

l  灰葡萄孢类泛素化（SUMO）分子BcSmt3生物学功能研究,中国博士后科学基金委员会，面上项目（2018M642450），2018-12至2020-06。

教育经历

[1]   2016.10-2018.3

Texas A&M University（美国得州农工大学）  |  微生物与植物互作  |  无学位  |  研究生教育

[2]   2012.9-2015.6

南京农业大学  |  农药学  |  硕士学位  |  硕士研究生毕业

[3]   2012.9-2018.6

南京农业大学  |  农药学  |  农学博士学位  |  博士研究生毕业

[4]   2007.9-2011.6

黑龙江八一农垦大学  |  植物保护  |  农学学士学位  |  大学本科毕业

工作经历

[1]   2018.8-2024.6

浙江大学  |  植物病理学

研究方向

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